T Cell–Derived IL-10 Impairs Host Resistance to Mycobacterium tuberculosis Infection

Tuberculosis (TB), caused by Mycobacterium tuberculosis infection, is a leading cause of mortality and morbidity, causing ∼1.5 million deaths annually. CD4(+) T cells and several cytokines, such as the Th1 cytokine IFN-γ, are critical in the control of this infection. Conversely, the immunosuppressi...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Moreira-Teixeira, Lúcia, Redford, Paul S., Stavropoulos, Evangelos, Ghilardi, Nico, Maynard, Craig L., Weaver, Casey T., Freitas do Rosário, Ana Paula, Wu, Xuemei, Langhorne, Jean, O’Garra, Anne
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2017
Soggetti:
Infectious Disease and Host Response
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502318/
https://ncbi.nlm.nih.gov/pubmed/28584007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601340
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