Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling

Tuberculosis causes ∼1.5 million deaths every year, thus remaining a leading cause of death from infectious diseases in the world. A growing body of evidence demonstrates that type I IFN plays a detrimental role in tuberculosis pathogenesis, likely by interfering with IFN-γ–dependent immunity. In th...

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Veröffentlicht in:J Immunol
Hauptverfasser: Moreira-Teixeira, Lúcia, Sousa, Jeremy, McNab, Finlay W., Torrado, Egídio, Cardoso, Filipa, Machado, Henrique, Castro, Flávia, Cardoso, Vânia, Gaifem, Joana, Wu, Xuemei, Appelberg, Rui, Castro, António Gil, O’Garra, Anne, Saraiva, Margarida
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2016
Schlagworte:
Infectious Disease and Host Response
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133670/
https://ncbi.nlm.nih.gov/pubmed/27849167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600584
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