Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung

IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(−/−) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and e...

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Detalhes bibliográficos
Main Authors: Redford, Paul S, Boonstra, Andre, Read, Simon, Pitt, Jonathan, Graham, Christine, Stavropoulos, Evangelos, Bancroft, Gregory J, O'Garra, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2010
Assuntos:
Immunity to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378704/
https://ncbi.nlm.nih.gov/pubmed/20518032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040433
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