fundTPL-2 – ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I Interferon Production()

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of mortality and morbidity worldwide, causing approximately 1.4 million deaths per year. Key immune components for host protection during tuberculosis include the cytokines IL-12, IL-1 and TNF-α, as well as IFN-γ and C...

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Huvudupphovsmän: McNab, Finlay W., Ewbank, John, Rajsbaum, Ricardo, Stavropoulos, Evangelos, Martirosyan, Anna, Redford, Paul S., Wu, Xuemei, Graham, Christine M., Saraiva, Margarida, Tsichlis, Philip, Chaussabel, Damien, Ley, Steven C., O’Garra, Anne
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796877/
https://ncbi.nlm.nih.gov/pubmed/23842752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300146
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