Antigen-Independent IFN-γ Production by Human Naïve CD4(+) T Cells Activated by IL-12 Plus IL-18

The role of T cells in innate immunity is not well defined. In this report, we show that a subset of human peripheral blood CD4(+) T cells responds to IL-12 plus IL-18, but not to IL-12 or IL-18 alone, by producing IFN-γ in the absence of any antigenic stimulation or cell proliferation. Intracellula...

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Detalhes bibliográficos
Main Authors: Munk, Rachel B., Sugiyama, Katsuki, Ghosh, Paritosh, Sasaki, Carl Y., Rezanka, Louis, Banerjee, Kasturi, Takahashi, Hidenori, Sen, Ranjan, Longo, Dan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091853/
https://ncbi.nlm.nih.gov/pubmed/21572994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018553
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