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Benzylpenicillin differentially conjugates to IFN-γ, TNF-α, IL-1β, IL-4 and IL-13 but selectively reduces IFN-γ activity
It is known that β-lactam antibiotics can conjugate to lysine and histidine residues on proteins via the carbonyl group of the opened β-lactam ring. However, it is not known which proteins these drugs target and there is little work addressing whether conjugation is preferential for some proteins ov...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Inc
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1808618/ https://ncbi.nlm.nih.gov/pubmed/12562387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2003.02069.x |
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