Benzylpenicillin differentially conjugates to IFN-γ, TNF-α, IL-1β, IL-4 and IL-13 but selectively reduces IFN-γ activity

It is known that β-lactam antibiotics can conjugate to lysine and histidine residues on proteins via the carbonyl group of the opened β-lactam ring. However, it is not known which proteins these drugs target and there is little work addressing whether conjugation is preferential for some proteins ov...

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Bibliographic Details
Main Authors: BROOKS, B M, THOMAS, A L, COLEMAN, J W
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Inc 2003
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1808618/
https://ncbi.nlm.nih.gov/pubmed/12562387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2003.02069.x
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