IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Maturation and selection of high-affinity B cell clones in the germinal center (GC) relies on support from T follicular helper (T(FH)) cells. T(FH) cells are characterized by their localization to the B cell follicle and their high expression of the costimulatory molecules ICOS and PD1 and the cytok...

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Main Authors: Batten, Marcel, Ramamoorthi, Nandhini, Kljavin, Noelyn M., Ma, Cindy S., Cox, Jennifer H., Dengler, Hart S., Danilenko, Dimitry M., Caplazi, Patrick, Wong, Melanie, Fulcher, David A., Cook, Matthew C., King, Cecile, Tangye, Stuart G., de Sauvage, Frederic J., Ghilardi, Nico
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005229/
https://ncbi.nlm.nih.gov/pubmed/21098093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100064
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