Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiota

Mammalian hosts are colonized with commensal microbes in various mucosal and epithelial tissues, including the intestinal tract. In mice, the presence of segmented filamentous bacteria (SFB) promotes Th17 differentiation and the development of autoimmune disease. Here, we demonstrate that the IL-23...

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Detalhes bibliográficos
Main Authors: Shih, Vincent Feng-Sheng, Cox, Jennifer, Kljavin, Noelyn M., Dengler, Hart S., Reichelt, Mike, Kumar, Pawan, Rangell, Linda, Kolls, Jay K., Diehl, Lauri, Ouyang, Wenjun, Ghilardi, Nico
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183330/
https://ncbi.nlm.nih.gov/pubmed/25201978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323852111
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