Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae

Interleukin (IL)-23 is a heterodimeric cytokine that shares the identical p40 subunit as IL-12 but exhibits a unique p19 subunit similar to IL-12 p35. IL-12/23 p40, interferon γ (IFN-γ), and IL-17 are critical for host defense against Klebsiella pneumoniae. In vitro, K. pneumoniae–pulsed dendritic c...

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Autors principals: Happel, Kyle I., Dubin, Patricia J., Zheng, Mingquan, Ghilardi, Nico, Lockhart, Christie, Quinton, Lee J., Odden, Anthony R., Shellito, Judd E., Bagby, Gregory J., Nelson, Steve, Kolls, Jay K.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212952/
https://ncbi.nlm.nih.gov/pubmed/16157683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050193
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