Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

Phosphatidylserine decarboxylase, which is embedded in the inner mitochondrial membrane, synthesizes phosphatidylethanolamine (PE) and, in some cells, synthesizes the majority of this important phospholipid. Normal levels of PE can decline with age in the brain. Here we used yeast and worms to test...

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Bibliografiske detaljer
Main Authors: Wang, Shaoxiao, Zhang, Siyuan, Liou, Liang-Chun, Ren, Qun, Zhang, Zhaojie, Caldwell, Guy A., Caldwell, Kim A., Witt, Stephan N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183298/
https://ncbi.nlm.nih.gov/pubmed/25201965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411694111
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