Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

Phosphatidylserine decarboxylase, which is embedded in the inner mitochondrial membrane, synthesizes phosphatidylethanolamine (PE) and, in some cells, synthesizes the majority of this important phospholipid. Normal levels of PE can decline with age in the brain. Here we used yeast and worms to test...

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Detalhes bibliográficos
Main Authors: Wang, Shaoxiao, Zhang, Siyuan, Liou, Liang-Chun, Ren, Qun, Zhang, Zhaojie, Caldwell, Guy A., Caldwell, Kim A., Witt, Stephan N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183298/
https://ncbi.nlm.nih.gov/pubmed/25201965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411694111
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