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Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease

Phosphatidylserine decarboxylase, which is embedded in the inner mitochondrial membrane, synthesizes phosphatidylethanolamine (PE) and, in some cells, synthesizes the majority of this important phospholipid. Normal levels of PE can decline with age in the brain. Here we used yeast and worms to test...

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書誌詳細
主要な著者: Wang, Shaoxiao, Zhang, Siyuan, Liou, Liang-Chun, Ren, Qun, Zhang, Zhaojie, Caldwell, Guy A., Caldwell, Kim A., Witt, Stephan N.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183298/
https://ncbi.nlm.nih.gov/pubmed/25201965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411694111
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