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A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast
Using a yeast model of Parkinson’s disease, we found that alpha-synuclein (αS) binds to lipid droplets in lipid-loaded, wild-type yeast cells but not to lipid droplet in lipid-loaded, peroxisome-deficient cells (pex3Δ).Our analysis revealed that pex3Δ cells have both fewer lipid droplets and smaller...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770730/ https://ncbi.nlm.nih.gov/pubmed/23916615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.07.100 |
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