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Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast
Hydroxyurea (HU) inhibits ribonucleotide reductase (RNR), which catalyzes the rate-limiting synthesis of deoxyribonucleotides for DNA replication. HU is used to treat HIV, sickle-cell anemia and some cancers. We found that, compared with vector control cells, low levels of alpha-synuclein (α-syn) pr...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3153305/ https://ncbi.nlm.nih.gov/pubmed/21642386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr246 |
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