The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

α-Synuclein (α-syn), a protein of unknown function, is the most abundant protein in Lewy bodies, the histological hallmark of Parkinson's disease (PD). In yeast α-syn inhibits endoplasmic reticulum (ER)-to-Golgi (ER→Golgi) vesicle trafficking, which is rescued by overexpression of a Rab GTPase...

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Detalhes bibliográficos
Main Authors: Gitler, Aaron D., Bevis, Brooke J., Shorter, James, Strathearn, Katherine E., Hamamichi, Shusei, Su, Linhui Julie, Caldwell, Kim A., Caldwell, Guy A., Rochet, Jean-Christophe, McCaffery, J. Michael, Barlowe, Charles, Lindquist, Susan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224176/
https://ncbi.nlm.nih.gov/pubmed/18162536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710685105
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