α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson’s Models

Alpha-synuclein (αSyn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson’s disease (PD). In yeast cells and in neurons αSyn accumulation is cytotoxic, but little is known about its normal function or pathobiology. The earliest defect following αSyn ex...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Cooper, Antony A., Gitler, Aaron D., Cashikar, Anil, Haynes, Cole M., Hill, Kathryn J., Bhullar, Bhupinder, Liu, Kangning, Xu, Kexiang, Strathearn, Katherine E., Liu, Fang, Cao, Songsong, Caldwell, Kim A., Caldwell, Guy A., Marsischky, Gerald, Kolodner, Richard D., LaBaer, Joshua, Rochet, Jean-Christophe, Bonini, Nancy M., Lindquist, Susan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2006
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1983366/
https://ncbi.nlm.nih.gov/pubmed/16794039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1129462
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