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Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and their Analogs

A stereoselective total synthesis of the cytotoxic natural products tubulysin U, tubulysin V, and its unnatural epimer epi-tubulysin V, is reported. A series of simplified analogs containing N,N-dimethyl-D-alanine as a replacement for the N-terminal N-Me-pipecolinic acid residue of the tubulysins is...

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Bibliografische gegevens
Hoofdauteurs: Balasubramanian, Ranganathan, Raghavan, Bhooma, Begaye, Adrian, Sackett, Dan L., Fecik, Robert A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183140/
https://ncbi.nlm.nih.gov/pubmed/19102699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8013579
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