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Total Synthesis and Biological Evaluation of Tubulysin U, Tubulysin V, and their Analogs
A stereoselective total synthesis of the cytotoxic natural products tubulysin U, tubulysin V, and its unnatural epimer epi-tubulysin V, is reported. A series of simplified analogs containing N,N-dimethyl-D-alanine as a replacement for the N-terminal N-Me-pipecolinic acid residue of the tubulysins is...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183140/ https://ncbi.nlm.nih.gov/pubmed/19102699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8013579 |
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