Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

We have previously shown that kava and its flavokavain-free Fraction B completely blocked 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice with a preferential reduction in NNK-induced O (6)-methylguanine (O (6)-mG). In this study, we first identified natura...

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Main Authors: Narayanapillai, Sreekanth C., Balbo, Silvia, Leitzman, Pablo, Grill, Alex E., Upadhyaya, Pramod, Shaik, Ahmad Ali, Zhou, Bo, O’Sullivan, M. Gerard, Peterson, Lisa A., Lu, Junxuan, Hecht, Stephen S., Xing, Chengguo
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178470/
https://ncbi.nlm.nih.gov/pubmed/25053626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu149
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