Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O(6)-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a key carcinogen responsible for tobacco smoke-induced lung carcinogenesis. Among the types of DNA damage caused by NNK and its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), O(6)-methylguanine (O(6)-mG) is likely the most ca...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Narayanapillai, Sreekanth C., Lin, Shang-Hsuan, Leitzman, Pablo, Upadhyaya, Pramod, Baglole, Carolyn J., Xing, Chengguo
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6532060/
https://ncbi.nlm.nih.gov/pubmed/27728767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00203
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