Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Effective chemopreventive agents are needed against lung cancer, the leading cause of cancer death. Results from our previous work showed that dietary dihydromethysticin (DHM) effectively blocked initiation of lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice, an...

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Publicado no:Drug Metab Dispos
Main Authors: Narayanapillai, Sreekanth C., von Weymarn, Linda B., Carmella, Steven G., Leitzman, Pablo, Paladino, Jordan, Upadhyaya, Pramod, Hecht, Stephen S., Murphy, Sharon E., Xing, Chengguo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767383/
https://ncbi.nlm.nih.gov/pubmed/26744252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068387
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