Oral dosing of dihydromethysticin ahead of tobacco carcinogen NNK effectively prevents lung tumorigenesis in A/J mice

Our early studies demonstrated an impressive chemopreventive efficacy of dihydromethysticin (DHM), unique in kava, against tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice, in which DHM was supplemented in the diet. The current work was c...

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Publicado en:Chem Res Toxicol
Autores principales: Hu, Qi, Corral, Pedro, Narayanapillai, Sreekanth C., Leitzman, Pablo, Upadhyaya, Pramod, O’Sullivan, M. Gerard, Hecht, Stephen S., Lu, Junxuan, Xing, Chengguo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8178726/
https://ncbi.nlm.nih.gov/pubmed/32476407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.0c00161
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