iPSC-Derived Neural Stem Cells Act via Kinase Inhibition to Exert Neuroprotective Effects in Spinal Muscular Atrophy with Respiratory Distress Type 1

Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a motor neuron disease caused by mutations in the IGHMBP2 gene, without a cure. Here, we demonstrate that neural stem cells (NSCs) from human-induced pluripotent stem cells (iPSCs) have therapeutic potential in the context of SMARD...

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Main Authors: Simone, Chiara, Nizzardo, Monica, Rizzo, Federica, Ruggieri, Margherita, Riboldi, Giulietta, Salani, Sabrina, Bucchia, Monica, Bresolin, Nereo, Comi, Giacomo P., Corti, Stefania
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176534/
https://ncbi.nlm.nih.gov/pubmed/25254343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.06.004
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