Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown–Vialetto disease that is partially rescued by riboflavin

Riboflavin is essential in numerous cellular oxidation/reduction reactions but is not synthesized by mammalian cells. Riboflavin absorption occurs through the human riboflavin transporters RFVT1 and RFVT3 in the intestine and RFVT2 in the brain. Mutations in these genes are causative for the Brown–V...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rizzo, Federica, Ramirez, Agnese, Compagnucci, Claudia, Salani, Sabrina, Melzi, Valentina, Bordoni, Andreina, Fortunato, Francesco, Niceforo, Alessia, Bresolin, Nereo, Comi, Giacomo P., Bertini, Enrico, Nizzardo, Monica, Corti, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382781/
https://ncbi.nlm.nih.gov/pubmed/28382968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46271
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