iPSC-Derived Neural Stem Cells Act via Kinase Inhibition to Exert Neuroprotective Effects in Spinal Muscular Atrophy with Respiratory Distress Type 1

Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a motor neuron disease caused by mutations in the IGHMBP2 gene, without a cure. Here, we demonstrate that neural stem cells (NSCs) from human-induced pluripotent stem cells (iPSCs) have therapeutic potential in the context of SMARD...

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Detalhes bibliográficos

Principais autores:	Chiara Simone, Monica Nizzardo, Federica Rizzo, Margherita Ruggieri, Giulietta Riboldi, Sabrina Salani, Monica Bucchia, Nereo Bresolin, Giacomo P. Comi, Stefania Corti
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2014-08-01
coleção:	Stem Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213671114001908
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