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Multiple LacI-mediated loops revealed by Bayesian statistics and tethered particle motion

The bacterial transcription factor LacI loops DNA by binding to two separate locations on the DNA simultaneously. Despite being one of the best-studied model systems for transcriptional regulation, the number and conformations of loop structures accessible to LacI remain unclear, though the importan...

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Autors principals: Johnson, Stephanie, van de Meent, Jan-Willem, Phillips, Rob, Wiggins, Chris H., Lindén, Martin
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176382/
https://ncbi.nlm.nih.gov/pubmed/25120267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku563
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