Multiple LacI-mediated loops revealed by Bayesian statistics and tethered particle motion

The bacterial transcription factor LacI loops DNA by binding to two separate locations on the DNA simultaneously. Despite being one of the best-studied model systems for transcriptional regulation, the number and conformations of loop structures accessible to LacI remain unclear, though the importan...

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Détails bibliographiques
Auteurs principaux: Johnson, Stephanie, van de Meent, Jan-Willem, Phillips, Rob, Wiggins, Chris H., Lindén, Martin
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Computational Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176382/
https://ncbi.nlm.nih.gov/pubmed/25120267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku563
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