A Novel Non-agonist Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand UHC1 Blocks PPARγ Phosphorylation by Cyclin-dependent Kinase 5 (CDK5) and Improves Insulin Sensitivity

Thiazolidinedione class of anti-diabetic drugs which are known as peroxisome proliferator-activated receptor γ (PPARγ) ligands have been used to treat metabolic disorders, but thiazolidinediones can also cause several severe side effects, including congestive heart failure, fluid retention, and weig...

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Bibliografische gegevens
Hoofdauteurs: Choi, Sun-Sil, Kim, Eun Sun, Koh, Minseob, Lee, Soo-Jin, Lim, Donghyun, Yang, Yong Ryoul, Jang, Hyun-Jun, Seo, Kyung-ah, Min, Sang-Hyun, Lee, In Hee, Park, Seung Bum, Suh, Pann-Ghill, Choi, Jang Hyun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2014
Onderwerpen:
Metabolism
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176243/
https://ncbi.nlm.nih.gov/pubmed/25100724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566794
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