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A Systems Biology Analysis of Apoptosome Formation and Apoptosis Execution Supports Allosteric Procaspase-9 Activation

The protease caspase-9 is activated on the apoptosome, a multiprotein signal transduction platform that assembles in response to mitochondria-dependent apoptosis initiation. Despite extensive molecular research, the assembly of the holo-apoptosome and the process of caspase-9 activation remain incom...

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Detalhes bibliográficos
Main Authors: Würstle, Maximilian L., Rehm, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176236/
https://ncbi.nlm.nih.gov/pubmed/25107908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.590034
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