Requirements for 5′dRP/AP lyase activity in Ku

The non-homologous end joining (NHEJ) pathway is used in diverse species to repair chromosome breaks, and is defined in part by a requirement for Ku. We previously demonstrated mammalian Ku has intrinsic 5′ deoxyribosephosphate (5′dRP) and apurinic/apyrimidinic (AP) lyase activity, and showed this a...

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Главные авторы: Strande, Natasha T., Carvajal-Garcia, Juan, Hallett, Ryan A., Waters, Crystal A., Roberts, Steven A., Strom, Christina, Kuhlman, Brian, Ramsden, Dale A.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
Предметы:
Nucleic Acid Enzymes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176175/
https://ncbi.nlm.nih.gov/pubmed/25200085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku796
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