The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca(2+) and cAMP

Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as the cryopyrin-associated periodic syndromes (CAPS)(1). NLRP3 is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory...

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Hlavní autoři: Lee, Geun-Shik, Subramanian, Naeha, Kim, Andrew I., Aksentijevich, Ivona, Goldbach-Mansky, Raphaela, Sacks, David B., Germain, Ronald N., Kastner, Daniel L., Chae, Jae Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175565/
https://ncbi.nlm.nih.gov/pubmed/23143333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11588
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