The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca(2+) and cAMP

Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as the cryopyrin-associated periodic syndromes (CAPS)(1). NLRP3 is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Lee, Geun-Shik, Subramanian, Naeha, Kim, Andrew I., Aksentijevich, Ivona, Goldbach-Mansky, Raphaela, Sacks, David B., Germain, Ronald N., Kastner, Daniel L., Chae, Jae Jin
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175565/
https://ncbi.nlm.nih.gov/pubmed/23143333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11588
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы