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Connecting Two Pathways through Ca(2+) Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic PLCG2 Mutation
OBJECTIVE: Previously, we reported that a novel variant, p.Ser707Tyr, in phospholipase Cγ2 (PLCγ2) is the cause of a dominantly inherited autoinflammatory disease, APLAID. The hypermorphic mutation enhances the PLCγ2 activity and causes an increase in intracellular Ca(2+) release from ER stores. As...
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| Wydane w: | Arthritis Rheumatol |
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| Główni autorzy: | , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2015
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4369162/ https://ncbi.nlm.nih.gov/pubmed/25418813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38961 |
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