Connecting Two Pathways through Ca(2+) Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic PLCG2 Mutation

OBJECTIVE: Previously, we reported that a novel variant, p.Ser707Tyr, in phospholipase Cγ2 (PLCγ2) is the cause of a dominantly inherited autoinflammatory disease, APLAID. The hypermorphic mutation enhances the PLCγ2 activity and causes an increase in intracellular Ca(2+) release from ER stores. As...

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Publicat a:Arthritis Rheumatol
Autors principals: Chae, Jae J., Park, Yong H., Park, Chung, Hwang, Il-Young, Hoffmann, Patrycja, Kehrl, John H., Aksentijevich, Ivona, Kastner, Daniel L.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369162/
https://ncbi.nlm.nih.gov/pubmed/25418813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38961
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