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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca(2+) and cAMP
Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as the cryopyrin-associated periodic syndromes (CAPS)(1). NLRP3 is a key component of one of several distinct cytoplasmic multiprotein complexes (inflammasomes) that mediate the maturation of the proinflammatory...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4175565/ https://ncbi.nlm.nih.gov/pubmed/23143333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11588 |
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