Glatiramer Acetate and Nanny Proteins Restrict Access of the Multiple Sclerosis Autoantigen Myelin Basic Protein to the 26S Proteasome

We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome without ubiquitination. The previously suggested concept of charge-mediated interaction between MBP and the proteasome led us to attempt to compensate or mimic its positive charge to inhibit proteasomal degradation. W...

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Main Authors: Kuzina, Ekaterina, Kudriaeva, Anna, Smirnov, Ivan, Dubina, Michael V., Gabibov, Alexander, Belogurov, Alexey
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172982/
https://ncbi.nlm.nih.gov/pubmed/25276831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/926394
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