Ubiquitin-independent proteosomal degradation of myelin basic protein contributes to development of neurodegenerative autoimmunity

Recent findings indicate that the ubiquitin–proteasome system is involved in the pathogenesis of cancer as well as autoimmune and several neurodegenerative diseases, and is thus a target for novel therapeutics. One disease that is related to aberrant protein degradation is multiple sclerosis, an aut...

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Udgivet i:FASEB J
Main Authors: Belogurov, Alexey, Kuzina, Ekaterina, Kudriaeva, Anna, Kononikhin, Alexey, Kovalchuk, Sergey, Surina, Yelena, Smirnov, Ivan, Lomakin, Yakov, Bacheva, Anna, Stepanov, Alexey, Karpova, Yaroslava, Lyupina, Yulia, Kharybin, Oleg, Melamed, Dobroslav, Ponomarenko, Natalia, Sharova, Natalia, Nikolaev, Eugene, Gabibov, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2015
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415016/
https://ncbi.nlm.nih.gov/pubmed/25634956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-259333
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