Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice

OBJECTIVE: Kindlin-3 is a critical supporter of integrin function in platelets. Lack of expression of kindlin-3 protein in patients impairs integrin αIIbβ3-mediated platelet aggregation. Although kindlin-3 has been categorized as an integrin-binding partner, the functional significance of the direct...

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Autori principali: Xu, Zhen, Chen, Xue, Zhi, Huiying, Gao, Juan, Bialkowska, Katarzyna, Byzova, Tatiana V, Pluskota, Elzbieta, White, Gilbert C., Liu, Junling, Plow, Edward F., Ma, Yan-Qing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167429/
https://ncbi.nlm.nih.gov/pubmed/24969775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.114.303851
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