Kindlin-2 directly binds actin and regulates integrin outside-in signaling

Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2(+/−) mice or C2C12 myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton and decreased spreading. These marked changes led us to examine direct binding between K2 and actin. Purified K2 interac...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Bledzka, Kamila, Bialkowska, Katarzyna, Sossey-Alaoui, Khalid, Vaynberg, Julia, Pluskota, Elzbieta, Qin, Jun, Plow, Edward F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2016
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828686/
https://ncbi.nlm.nih.gov/pubmed/27044892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201501006
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