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Kindlin-2 directly binds actin and regulates integrin outside-in signaling

Reduced levels of kindlin-2 (K2) in endothelial cells derived from K2(+/−) mice or C2C12 myoblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton and decreased spreading. These marked changes led us to examine direct binding between K2 and actin. Purified K2 interac...

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Vydáno v:J Cell Biol
Hlavní autoři: Bledzka, Kamila, Bialkowska, Katarzyna, Sossey-Alaoui, Khalid, Vaynberg, Julia, Pluskota, Elzbieta, Qin, Jun, Plow, Edward F.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828686/
https://ncbi.nlm.nih.gov/pubmed/27044892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201501006
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