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Tyrosine Phosphorylation of Integrin β(3) Regulates Kindlin-2 Binding and Integrin Activation

Kindlins are essential for integrin activation in cell systems and do so by working in a cooperative fashion with talin via their direct interaction with integrin β cytoplasmic tails (CTs). Kindlins interact with the membrane-distal NxxY motif, which is distinct from the talin-binding site within th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bledzka, Kamila, Bialkowska, Katarzyna, Nie, Huiqin, Qin, Jun, Byzova, Tatiana, Wu, Chuanyue, Plow, Edward F., Ma, Yan-Qing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945529/
https://ncbi.nlm.nih.gov/pubmed/20702409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.134247
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