Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin

Kindlins play an important role in supporting integrin activation by cooperating with talin; however, the mechanistic details remain unclear. Here, we show that kindlins interacted directly with paxillin and that this interaction could support integrin αIIbβ3 activation. An exposed loop in the N-ter...

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Veröffentlicht in:J Cell Sci
Hauptverfasser: Gao, Juan, Huang, Ming, Lai, Jingjing, Mao, Kaijun, Sun, Peisen, Cao, Zhongyuan, Hu, Youpei, Zhang, Yingying, Schulte, Marie L., Jin, Chaozhi, Wang, Jian, White, Gilbert C., Xu, Zhen, Ma, Yan-Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040092/
https://ncbi.nlm.nih.gov/pubmed/28954813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.205641
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