Structure basis of the FERM domain of kindlin-3 in supporting integrin αIIbβ3 activation in platelets

Kindlin-3, a protein 4.1, ezrin, radixin, and moesin (FERM) domain–containing adaptor in hematopoietic cells, is essentially required for supporting the bidirectional integrin αIIbβ3 signaling in platelets by binding to the integrin β3 cytoplasmic tail. However, the structural details of kindlin-3’s...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Sun, Jiaojiao, Xiao, Desheng, Ni, Yuan, Zhang, Tianlong, Cao, Zhongyuan, Xu, Zhou, Nguyen, Huong, Zhang, Jun, White, Gilbert C., Ding, Jianping, Ma, Yan-Qing, Xu, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362375/
https://ncbi.nlm.nih.gov/pubmed/32649767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001575
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