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Junctional adhesion molecule-A suppresses platelet integrin α(IIb)β(3) signaling by recruiting Csk to the integrin-c–Src complex
Fibrinogen binding to activated integrin induces outside-in signaling that results in stable platelet aggregates and clot retraction. How integrin α(IIb)β(3) is discouraged from spontaneous activation is not known. We have recently shown that junctional adhesion molecule-A (JAM-A) renders protection...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938150/ https://ncbi.nlm.nih.gov/pubmed/24300854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-496232 |
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