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Junctional adhesion molecule-A suppresses platelet integrin α(IIb)β(3) signaling by recruiting Csk to the integrin-c–Src complex

Fibrinogen binding to activated integrin induces outside-in signaling that results in stable platelet aggregates and clot retraction. How integrin α(IIb)β(3) is discouraged from spontaneous activation is not known. We have recently shown that junctional adhesion molecule-A (JAM-A) renders protection...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Naik, Meghna U., Caplan, Jeffrey L., Naik, Ulhas P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2014
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938150/
https://ncbi.nlm.nih.gov/pubmed/24300854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-496232
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