Structure basis of the FERM domain of kindlin-3 in supporting integrin αIIbβ3 activation in platelets

Kindlin-3, a protein 4.1, ezrin, radixin, and moesin (FERM) domain–containing adaptor in hematopoietic cells, is essentially required for supporting the bidirectional integrin αIIbβ3 signaling in platelets by binding to the integrin β3 cytoplasmic tail. However, the structural details of kindlin-3’s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood Adv
Prif Awduron: Sun, Jiaojiao, Xiao, Desheng, Ni, Yuan, Zhang, Tianlong, Cao, Zhongyuan, Xu, Zhou, Nguyen, Huong, Zhang, Jun, White, Gilbert C., Ding, Jianping, Ma, Yan-Qing, Xu, Zhen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2020
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362375/
https://ncbi.nlm.nih.gov/pubmed/32649767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001575
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