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ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding

ADAP is a hematopoietic-restricted adapter protein that promotes integrin activation and is a carrier for other adapter proteins, Src kinase–associated phosphoprotein 1 (SKAP1) and SKAP2. In T lymphocytes, SKAP1 is the ADAP-associated molecule that activates integrins through direct linkages with Ra...

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Bibliografische gegevens
Hoofdauteurs: Kasirer-Friede, Ana, Kang, Jian, Kahner, Bryan, Ye, Feng, Ginsberg, Mark H., Shattil, Sanford J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023421/
https://ncbi.nlm.nih.gov/pubmed/24523237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-520627
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