Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin αIIbβ3

Platelet aggregation requires agonist-induced αIIbβ3 activation, a process mediated by Rap1 and talin. To study mechanisms, we engineered αIIbβ3 Chinese hamster ovary (CHO) cells to conditionally express talin and protease-activated receptor (PAR) thrombin receptors. Human PAR1 or murine PAR4 stimul...

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Detalhes bibliográficos
Main Authors: Watanabe, Naohide, Bodin, Laurent, Pandey, Manjula, Krause, Matthias, Coughlin, Shaun, Boussiotis, Vassiliki A., Ginsberg, Mark H., Shattil, Sanford J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442211/
https://ncbi.nlm.nih.gov/pubmed/18573917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200803094
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