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Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3

Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is sufficient to activate purified integrin αIIbβ3 in vitro. S...

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Hlavní autoři: Kahner, Bryan N., Kato, Hisashi, Banno, Asoka, Ginsberg, Mark H., Shattil, Sanford J., Ye, Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311585/
https://ncbi.nlm.nih.gov/pubmed/22457811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034056
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