The antithrombotic potential of selective blockade of talin-dependent integrin α(IIb)β(3) (platelet GPIIb–IIIa) activation

In vitro studies indicate that binding of talin to the β(3) integrin cytoplasmic domain (tail) results in integrin α(IIb)β(3) (GPIIb–IIIa) activation. Here we tested the importance of talin binding for integrin activation in vivo and its biological significance by generating mice harboring point mut...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Petrich, Brian G., Fogelstrand, Per, Partridge, Anthony W., Yousefi, Nima, Ablooglu, Ararat J., Shattil, Sanford J., Ginsberg, Mark H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2007
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906732/
https://ncbi.nlm.nih.gov/pubmed/17627302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31024
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia