The antithrombotic potential of selective blockade of talin-dependent integrin α(IIb)β(3) (platelet GPIIb–IIIa) activation

In vitro studies indicate that binding of talin to the β(3) integrin cytoplasmic domain (tail) results in integrin α(IIb)β(3) (GPIIb–IIIa) activation. Here we tested the importance of talin binding for integrin activation in vivo and its biological significance by generating mice harboring point mut...

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Detalhes bibliográficos
Main Authors: Petrich, Brian G., Fogelstrand, Per, Partridge, Anthony W., Yousefi, Nima, Ablooglu, Ararat J., Shattil, Sanford J., Ginsberg, Mark H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906732/
https://ncbi.nlm.nih.gov/pubmed/17627302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31024
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