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Antithrombotic effects of targeting αIIbβ3 signaling in platelets
αIIbβ3 interaction with fibrinogen promotes Src-dependent platelet spreading in vitro. To determine the consequences of this outside-in signaling pathway in vivo, a “β3(Δ760-762)” knockin mouse was generated that lacked the 3 C-terminal β3 residues (arginine-glycine-threonine [RGT]) necessary for αI...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society of Hematology
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668853/ https://ncbi.nlm.nih.gov/pubmed/19005179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-180687 |
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