Group IVA cytosolic phospholipase A(2) (cPLA(2)α) and integrin αIIbβ3 reinforce each other's functions during αIIbβ3 signaling in platelets

Group IVA cytosolic phospholipase A(2) (cPLA(2)α) catalyzes release of arachidonic acid from glycerophospholipids, leading to thromboxane A(2) (TxA(2)) production. Some platelet agonists stimulate cPLA(2)α, but others require fibrinogen binding to αIIbβ3 to elicit TxA(2). Therefore, relationships be...

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Detalhes bibliográficos
Main Authors: Prévost, Nicolas, Mitsios, John V., Kato, Hisashi, Burke, John E., Dennis, Edward A., Shimizu, Takao, Shattil, Sanford J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615656/
https://ncbi.nlm.nih.gov/pubmed/18840708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-162032
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